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Decrease in pain scores after vitamin B12 supplementation have been also reported in other types of pain such as peripheral neuropathy and post-chemotherapy musculoskeletal pain

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A regimen combining a loading dose and no loading dose, involving administration every three days for two weeks followed by weekly doses, appears to be the optimal approach for treating vitamin B12 deficiency in elderly patients.

As fibromyalgia causes widespread pain throughout the body, it is suspected that the brain and spinal cord changes in people with fibromyalgia, as the result of repeated nerve stimulation

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